Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research Progress on the Role of AMPK Signaling Pathway in the Regulation of Neural Injury.

Current topics in medicinal chemistry·2026
Same author

Prevalence and associated factors of liver fibrosis and steatosis in Gansu, China: a community-based cross-sectional study.

BMC public health·2026
Same author

Antioxidant Activity and Metabolomic Characterization of <i>Lactiplantibacillus plantarum</i> MCS1903 Isolated from Naturally Fermented Tofu Whey.

Microorganisms·2026
Same author

Tirofiban for Reduction of TEAR: A Phase 2, Randomized, Open-Label, Blinded End Point, Controlled Trial.

Stroke·2026
Same author

A study on the application of range shifter and bolus in spot-scanning proton arc (SPArc) therapy after modified radical mastectomy for left-sided breast cancer.

Frontiers in public health·2026
Same author

Development and validation of the pre-scope score for predicting incomplete occlusion after pipeline embolization.

European journal of radiology·2026

Related Experiment Video

Updated: Apr 30, 2026

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

3.5K

A highly sensitive plasmonic DNA assay based on triangular silver nanoprism etching.

Xinjian Yang1, Yuebo Yu, Zhiqiang Gao

  • 1Department of Chemistry, National University of Singapore , Singapore 117543.

ACS Nano
|April 29, 2014
PubMed
Summary

We developed a simple, low-cost DNA detection platform using silver nanoprism etching. This sensitive assay can detect extremely low DNA concentrations, aiding clinical diagnostics and mutation detection.

More Related Videos

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

3.6K
Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
09:33

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

Published on: March 21, 2025

1.4K

Related Experiment Videos

Last Updated: Apr 30, 2026

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

3.5K
Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

3.6K
Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
09:33

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

Published on: March 21, 2025

1.4K

Area of Science:

  • Nanotechnology
  • Biochemistry
  • Analytical Chemistry

Background:

  • Accurate nucleic acid detection is crucial for clinical diagnostics, mutation analysis, and biodefense.
  • Existing DNA quantification methods often rely on expensive and complex instrumentation.
  • There is a need for simple, low-cost, and highly sensitive DNA detection assays.

Purpose of the Study:

  • To develop a facile and cost-effective DNA detection platform.
  • To leverage plasmonic properties of silver nanoprisms for enhanced sensitivity.
  • To combine amplification techniques with nanoprism-based detection for ultra-sensitive DNA quantification.

Main Methods:

  • Utilized a plasmonic triangular silver nanoprism etching process.
  • Engineered changes in nanoprism shape and size, inducing surface plasmon resonance shifts.
  • Integrated enzyme-linked hybridization chain reaction (HCR) amplification with the nanoprism assay.

Main Results:

  • Achieved a detection limit as low as 6.0 femtomolar (fM) for target DNA.
  • Demonstrated high sensitivity and selectivity through the combined HCR and plasmonic nanoprism approach.
  • The assay showed significant surface plasmon resonance shifts due to nanoprism alteration.

Conclusions:

  • The developed plasmonic DNA assay offers a simple, low-cost, and highly sensitive method for nucleic acid detection.
  • This platform has significant potential for applications in clinical diagnostics and mutation detection.
  • The combination of HCR amplification and silver nanoprism etching provides a powerful tool for ultra-trace DNA quantification.