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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

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Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Physicochemical characterization techniques for solid lipid nanoparticles: principles and limitations.

Niranjan Kathe1, Brian Henriksen, Harsh Chauhan

  • 1Pharmacy Sciences, Creighton University , Omaha, NE , USA.

Drug Development and Industrial Pharmacy
|April 29, 2014
PubMed
Summary
This summary is machine-generated.

Solid lipid nanoparticles (SLNs) offer advantages for drug delivery, encapsulating various compounds. This review covers SLN preparation, characterization, and functionality assays for effective in vivo performance.

Keywords:
Lipid polymorphismSLNparticle sizephysico chemical characterizationpoorly soluble drugsprotein deliveryzeta potential

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Area of Science:

  • Nanotechnology
  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Solid lipid nanoparticles (SLNs) are increasingly recognized as a versatile drug delivery system.
  • They offer advantages such as incorporating poorly soluble drugs, proteins, and biologicals.
  • SLNs are prepared using various lipids and surfactants via methods like high-pressure homogenization and sonication.

Purpose of the Study:

  • To review the importance of SLNs in drug delivery.
  • To emphasize the principles and limitations of SLN physicochemical characterization.
  • To highlight the significance of functionality assays for predicting in vivo performance.

Main Methods:

  • Discussion of preparation techniques including high-pressure homogenization and sonication.
  • Overview of physicochemical characterization methods: particle size analysis, zeta potential, crystallinity/polymorphism determination.
  • Emphasis on drug loading, entrapment efficiency, and in vivo functionality assays.

Main Results:

  • SLNs demonstrate significant potential for delivering a wide range of therapeutic agents.
  • Physicochemical characterization is crucial for ensuring SLN quality and performance.
  • Functionality assays are essential for validating the in vivo efficacy of SLN formulations.

Conclusions:

  • Solid lipid nanoparticles (SLNs) are a promising platform for advanced drug delivery.
  • Comprehensive physicochemical characterization and functional assessment are vital for successful SLN development.
  • Further research into SLN principles and limitations will enhance their therapeutic applications.