Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Refractive surgery progress: LASIK, KLEx, and postoperative lens modulation.

Journal of cataract and refractive surgery·2026
Same author

Advancing subclinical keratoconus detection using polarization-sensitive optical coherence tomography and artificial intelligence.

Biophotonics discovery·2026
Same author

Re: Abdelmotaal et al: Artificial Intelligence-Derived Biomechanical Index for Early Corneal Ectasia Detection: Advancing Beyond Tomography.

Ophthalmology science·2026
Same author

In Vivo Biomechanical Characteristics of Human Corneas With Phase-Decorrelation OCT.

Investigative ophthalmology & visual science·2026
Same author

New evidence for effectiveness of intracameral moxifloxacin for postcataract surgery endophthalmitis prophylaxis.

Journal of cataract and refractive surgery·2025
Same author

Determining Stress Distribution in a Longitudinal Keratoconus Cohort.

Cornea·2025

Related Experiment Video

Updated: Apr 30, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

19.6K

Patterned corneal collagen crosslinking for astigmatism: computational modeling study.

Ibrahim Seven1, Abhijit Sinha Roy1, William J Dupps1

  • 1From Cole Eye Institute (Seven, Sinha Roy, Dupps), Ocular Biomechanics and Imaging Laboratory, and the Department of Biomedical Engineering (Seven, Dupps), Lerner Research Institute, Cleveland Clinic, and the Department of Chemical and Biomedical Engineering (Seven), Cleveland State University, Cleveland, Ohio, USA; Narayana Netralaya (Sinha Roy), Bangalore, India.

Journal of Cataract and Refractive Surgery
|April 29, 2014
PubMed
Summary
This summary is machine-generated.

Spatially selective corneal stromal stiffening can reduce corneal astigmatism. Computational models show patterned collagen crosslinking is effective, with results depending on patient geometry and treatment specifics.

More Related Videos

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

7.2K
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

8.4K

Related Experiment Videos

Last Updated: Apr 30, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

19.6K
Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

7.2K
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

8.4K

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Computational Science

Background:

  • Corneal astigmatism affects vision and can be treated with refractive surgery.
  • Corneal stromal stiffening is a potential therapeutic approach.
  • Understanding the spatial and geometric parameters of stiffening is crucial for optimizing treatment outcomes.

Purpose of the Study:

  • To investigate if targeted stiffening of the corneal stroma can correct corneal astigmatism.
  • To evaluate how treatment orientation, pattern, and material model complexity influence astigmatism correction in computational simulations.
  • To utilize patient-specific corneal geometries for realistic modeling.

Main Methods:

  • Generated 3D finite element models of corneas from 10 patients with astigmatism.
  • Simulated four different treatment patterns, varying orientation and stiffening magnitude.
  • Assessed the impact of material model complexity on simulated corneal curvature and aberrations.

Main Results:

  • Simulated treatments on the flat axis reduced corneal astigmatism, with effects varying by pattern geometry.
  • A linear bow-tie pattern showed the greatest mean astigmatism reduction (1.08 D).
  • Material model complexity did not significantly alter the mean astigmatic effect but influenced the coupling ratio.

Conclusions:

  • In silico modeling suggests patterned collagen crosslinking can significantly reduce astigmatism.
  • Treatment effectiveness is influenced by patient-specific corneal geometry, the chosen stiffening pattern, and its orientation.
  • Further research into optimizing these parameters could lead to improved clinical outcomes.