Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Glaucoma: Overview01:25

Glaucoma: Overview

1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological cleansing: Toward improving ocular surface surgical outcomes.

Indian journal of ophthalmology·2026
Same author

An objective assessment of vision performance at different reading distances after smooth incision lenticular keratomileusis (SILK) for myopia.

Scientific reports·2025
Same author

Role of hyaluronate containing artificial tears in mitigating markers of dry eye disease using in vitro models.

Indian journal of ophthalmology·2025
Same author

Epigenetic Modulation Directs Recovery Post LASIK and SMILE Surgery: An Experimental Study.

Life (Basel, Switzerland)·2025
Same author

Repeatability and agreement of a new anterior segment optical coherence tomography with standard devices in normal, keratoconus, and post-refractive eyes.

Indian journal of ophthalmology·2025
Same author

Evaluation of change in the orientation of intraocular lens in the bag using intraoperative spectral-domain optical coherence tomography before and after capsular tension ring implantation.

Indian journal of ophthalmology·2025

Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.7K

Advancing subclinical keratoconus detection using polarization-sensitive optical coherence tomography and artificial

Rahul P Patil1,2, Raghav Narasimhan1, Anchana Pisharody1

  • 1Narayana Nethralaya Foundation, Imaging, Biomechanics and Mathematical Modelling Solutions Laboratory, Bangalore, Karnataka, India.

Biophotonics Discovery
|April 24, 2026
PubMed
Summary

Polarization-sensitive optical coherence tomography (PS-OCT) shows promise in detecting subclinical keratoconus (SKC). While AI models performed similarly for healthy and KC eyes, PS-OCT offered unique insights into SKC classification, aiding refractive surgery decisions.

Keywords:
artificial-intelligenceclassification.corneakeratoconuspolarization-sensitiveps-oct

More Related Videos

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

11.0K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.0K

Related Experiment Videos

Last Updated: Apr 25, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.7K
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

11.0K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.0K

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Keratoconus (KC) is a progressive corneal disease where early detection is challenging.
  • Polarization-sensitive optical coherence tomography (PS-OCT) quantifies corneal birefringence, reflecting collagen organization and integrity.

Purpose of the Study:

  • To evaluate PS-OCT-derived phase retardation and corneal sublayer thickness as biomarkers for healthy, subclinical KC (SKC), and KC.
  • To compare the performance of AI classification models using PS-OCT, Pentacam, and MS-39 data for diagnosing KC and SKC.

Main Methods:

  • 359 eyes were analyzed using PS-OCT, Pentacam, and MS-39 imaging devices.
  • AI-based random forest classifiers were trained with a leave-one-out methodology for performance comparison.
  • PS-OCT derived phase retardation and corneal sublayer thickness were explored as diagnostic biomarkers.

Main Results:

  • AI models showed comparable accuracy for healthy and KC detection across all devices.
  • PS-OCT reclassified 39.5% of SKC eyes as healthy, differing from Pentacam (27.5%) and MS-39 (30.3%).
  • PS-OCT achieved an AUC of 0.91, precision of 83%, recall of 82%, F1 score of 0.82, and accuracy of 82% for SKC detection.

Conclusions:

  • AI model agreement was high for healthy and KC but varied for SKC.
  • PS-OCT offers complementary diagnostic value, potentially improving subclinical KC detection.
  • Enhanced SKC detection using PS-OCT can inform safer refractive surgery decisions.