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Updated: Apr 30, 2026

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase
A Jadoon1, P Cunningham2, L C McDermott1
1Diabetes and Nutritional Sciences Division, School of Medicine, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK.
Abstract:
Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition. We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition.
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