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Updated: Apr 30, 2026

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
Published on: February 23, 2024
Pseudoangiosarcomatous squamous cell carcinoma developing on a burn scar: a case report and review of the literature
Sung Hoon Koh1, Suk Joon Oh2, Huan Chun2
1Department of Plastic and Reconstructive Surgery, Hallym University Sacred Heart Hospital, Anyangsi, Republic of Korea.
Abstract:
Pseudoangiosarcomatous squamous cell carcinoma, also known as pseudovascular, pseudovascular adenoid and pseudoangiomatous squamous cell carcinoma, is an exceedingly rare, aggressive variant of cutaneous squamous cell carcinoma with extreme acantholysis resulting in angiosarcoma-like areas. Histologically, a pseudoangiosarcomatous pattern includes complex anastomosing channels and spaces lined with neoplastic cells. The neoplastic cells exhibit cytokeratin and vimentin positivity but yield negative results with CD31 and CD34. This case report describes pseudoangiosarcomatous squamous cell carcinoma developing on a burn scar on the ankle. In this report, we emphasize the importance of establishing a diagnosis with histological and immunohistochemical examination, and we review the described incidence of the age and sites with the prognosis for the treatment of pseudoangiosarcomatous squamous cell carcinoma of the skin.
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