Related Experiment Videos
Effects of protamine on histamine release from human lung
J H Levy1, B A Faraj, J R Zaidan
1Department of Anesthesia, Emory University School of Medicine, Atlanta, GA 30322.
Agents and Actions
|August 1, 1989
Abstract:
Animal mast cell models demonstrate direct histamine release by protamine. Investigators have proposed that protamine also releases histamine in man. We studied the effects of protamine alone and heparin-protamine mixtures on minced lung tissue for evidence of histamine release. We were unable to demonstrate the release of histamine despite positive anti-IgE controls. Nonimmunologic histamine release from human lung appears unlikely as a mechanism for protamine reactions in man.