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Published on: February 23, 2020
Red cell distribution width is increased in patients with ascending aortic dilatation
Barış Güngör1, Kazım Serhan Ozcan1, Fatma Ozpamuk Karadeniz1
1Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, İstanbul, Turkey.
Red cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) are elevated in patients with ascending aortic dilatation (AAD). Increased RDW levels may help predict AAD, suggesting inflammation plays a role in its development.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Inflammation Research
Background:
- Ascending aortic dilatation (AAD) is a cardiovascular disease linked to aortic wall inflammation and degeneration.
- Red cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) are established prognostic markers in cardiovascular diseases.
Purpose of the Study:
- To investigate the association between serum RDW and NLR levels and the presence of AAD.
- To determine if RDW and NLR can serve as biomarkers for AAD.
Main Methods:
- Prospective study comparing 200 patients with AAD to 170 controls.
- Analysis of complete blood counts (CBCs) including RDW and NLR.
- Comparison of CBC results from within two years prior to diagnosis.
Main Results:
- Patients with AAD had significantly higher RDW, NLR, and hs-CRP levels compared to controls.
- Ascending aortic diameter correlated with RDW and NLR.
- Multivariate analysis identified RDW and hs-CRP as independent correlates of AAD.
- RDW >13.8% predicted AAD with 82.8% specificity.
Conclusions:
- Elevated RDW and hs-CRP levels are observed in patients with AAD.
- These findings suggest a potential role for inflammation in the pathogenesis of AAD.
- RDW may serve as a predictive biomarker for AAD.
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