Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense
Yu V Nesterova1, T N Povetieva, N I Suslov
1Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, nes-yuliya@yandex.ru.
Bulletin of Experimental Biology and Medicine
|April 29, 2014
Abstract:
We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene alkaloids exerted no ulcerogenic effect.
