Related Experiment Video
Updated: Aug 8, 2026

Isolation of Murine Embryonic Hemogenic Endothelial Cells
Published on: June 17, 2016
Mesoderm induction and blood island formation by angiogenic growth factors and embryonic inducing factors
W Knöchel1, H Grunz, B Loppnow-Blinde
1Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Federal Republic of Germany.
Abstract:
Factors which induce mesoderm, including endothelium lined cavities and primitive blood cells in omnipotent amphibian ectoderm, have been isolated from different sources. Recently it was shown that angiogenic factors, which belong to the protein families of the heparin binding growth factors (acidic and basic fibroblast growth factor) and the transforming growth factors (TGF-beta 1 and -beta 2), also induce mesodermal tissues in amphibian ectoderm. In triturus ectoderm, capillary like endothelial networks are induced preferentially by the transforming growth factors. The relationship between growth factors and inducing factors is discussed.
Related Concept Videos
Gastrulation
Determination
Mechanism of Angiogenesis
Regulation of Angiogenesis and Blood Supply
Hematopoiesis
Development of Blood Vessels
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

