Related Experiment Video
Updated: Apr 30, 2026
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Comparative evaluation of opioid-induced changes in immune reactivity of CBA mice
M A Cheido1, M M Gevorgyan, E N Zhukova
1Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, cheido@physiol.ru.
Comparison of IgM and IgG-humoral immune response of CBA mice immunized with SE (5 × 10(8) cells) to activation of μ- (DAGO, 100 μg/kg) and δ2- (DSLET, 100 μg/kg) opioid receptors was studied. Different effects of opioids on IgM and IgG antibody production and peripheral blood and spleen levels of CD4(+) and CD8(+) subpopulations were detected at the peak of immune response under these conditions.
Comparison of IgM and IgG-humoral immune response of CBA mice immunized with SE (5 × 10(8) cells) to activation of μ- (DAGO, 100 μg/kg) and δ2- (DSLET, 100 μg/kg) opioid receptors was studied. Different effects of opioids on IgM and IgG antibody production and peripheral blood and spleen levels of CD4(+) and CD8(+) subpopulations were detected at the peak of immune response under these conditions.
