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Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
Published on: August 9, 2024
Functions of volume-sensitive and calcium-activated chloride channels
Else Kay Hoffmann1, Niels Bjerre Holm, Ian Henry Lambert
1Department of Biology, University of Copenhagen, 13 Universitetsparken, Copenhagen Ø, Denmark.
Abstract:
The review describes molecular and functional properties of the volume regulated anion channel and Ca(2+)-dependent Cl(-) channels belonging to the anoctamin family with emphasis on physiological importance of these channels in regulation of cell volume, cell migration, cell proliferation, and programmed cell death. Finally, we discuss the role of Cl(-) channels in various diseases.
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