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ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes

A Chobot1, J Wenzlau, K Bak-Drabik

  • 1Clinical Hospital No1, Zabrze, Poland.

Clinical and Experimental Immunology
|April 30, 2014
PubMed

Insights

Autoantibodies to ATP4A (ATP4AA) are found in 30% of children with type 1 diabetes, and are more common in females. Helicobacter pylori infection was not associated with ATP4AA presence in this study.

Area of Science:

  • Endocrinology
  • Immunology
  • Gastroenterology

Background:

  • Autoimmune atrophic body gastritis (ABG) is characterized by autoantibodies to ATP4A (ATP4AA).
  • ABG is associated with type 1 diabetes, a common autoimmune endocrine disorder in children.
  • Helicobacter pylori (Hp) infection is a common cause of gastritis and has been implicated in autoimmune processes.

Purpose of the Study:

  • To investigate the association between Helicobacter pylori infection and the presence of ATP4AA in children with type 1 diabetes.
  • To determine the prevalence of ATP4AA in a cohort of children with type 1 diabetes.
  • To explore potential associations between ATP4AA and clinical parameters in pediatric type 1 diabetes.

Main Methods:

  • A cross-sectional study involving 70 children with type 1 diabetes.
  • ATP4AA were measured using a radioimmunoprecipitation assay.
  • Helicobacter pylori infection was detected using the 13C urea breath test.

Main Results:

  • ATP4AA were present in 30% of the children, with a higher prevalence in females (42%) compared to males (16%).
  • Helicobacter pylori infection was detected in 33% of the children.
  • No statistically significant association was found between ATP4AA positivity and Hp infection status, age, age at diagnosis, diabetes duration, or HbA1c levels.

Conclusions:

  • ATP4AA are prevalent in approximately one-third of children with type 1 diabetes, particularly in females.
  • Helicobacter pylori infection does not appear to be associated with the development of parietal cell autoimmunity in this pediatric cohort.
  • Further research may explore other potential triggers or contributing factors for ATP4AA in children with type 1 diabetes.

Keywords:
Helicobacter pyloriautoantibodiesautoimmune gastritisparietal celltype 1 diabetes

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