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Diagnostic capacity of biomechanical indices from a dynamic bidirectional applanation device in pellucid marginal
Georgios Labiris1, Athanassios Giarmoukakis1, Haris Sideroudi1
1From the Department of Ophthalmology (Labiris, Song, Seitz, Gatzioufas), University Medical Center of Saarland UKS, Homburg/Saar, Germany; the Eye Institute of Thrace (Labiris, Giarmoukakis, Sideroudi, Kozobolis,), Alexandroupolis, Greece.
Purpose:
To evaluate the diagnostic capacity of the keratoconus match index (KMI) and keratoconus match probability (KMP) classification from a dynamic bidirectional applanation device (Ocular Response Analyzer) in eyes with pellucid marginal degeneration (PMD).
Setting:
Department of Ophthalmology, University Clinics Saarland, Homburg, Germany.
Design:
Cross-sectional study.
Methods:
Pellucid marginal degeneration eligibility was confirmed by inferior peripheral thinning, corneal protrusion, and irregular astigmatism. The KMI and KMP parameters in PMD eyes (study group) were compared with those in normal eyes (control group). The KMI's overall predictive accuracy was assessed operating characteristic (ROC) curves. The relationship between KMI and corneal hysteresis (CH), the corneal resistance factor (CRF), and a series of Scheimpflug camera indices was evaluated with Spearman analysis (r).
Results:
The mean KMI in the study group (40 eyes) and control group (40 eyes) was 0.34 ± 0.43 (SD) and 0.95 ± 0.30, respectively (P<.001). The KMI correlated significantly with the CH, CRF, and most Scheimpflug camera indices. Regression analysis indicated that the index of height decentration (r = -0.877, P<.001) was the primary determinant of the KMI. Moreover, the KMP index identified 50.0%, 29.16%, and 20.83% of PMD eyes as ectatic, suspect for ectasia, and normal, respectively. The ROC curve analysis of the KMI parameter indicated a predictive accuracy of 94.8% (cutoff point 0.626; sensitivity 85.71%; specificity 90.1%).
Conclusions:
The KMI seems to be a promising diagnostic index for PMD. In contrast, the KMP index identified a significant percentage of topographically defined PMD eyes as normal, limiting its diagnostic value in PMD.
Financial Disclosures:
No author has a financial or proprietary interest in any material or method mentioned.
