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United States birth weight reference corrected for implausible gestational age estimates.

Nicole M Talge1, Lanay M Mudd2, Alla Sikorskii3

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Summary

This study presents an updated US birth weight reference, correcting for dating errors to accurately assess infant size. The new reference improves the classification of birth weight for gestational age for better clinical use.

Keywords:
United Statesbirth weightgestational agegrowth chartsreferencesmall for gestational age

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Research
  • Biostatistics

Background:

  • Accurate birth weight for gestational age (BWGA) assessment is crucial for neonatal health monitoring.
  • Existing US BWGA references may contain errors due to inaccurate gestational age dating, primarily from last menstrual period (LMP) estimations.
  • Need for an updated, reliable BWGA reference for clinical and research applications.

Purpose of the Study:

  • To develop an updated US-based BWGA reference.
  • To correct for potential errors in gestational age dating, particularly LMP-based estimates.
  • To provide means, SDs, and percentiles for calculating continuous and categorical BWGA measures.

Main Methods:

  • Utilized 2009-2010 US live birth data for singleton births (22-44 weeks gestation).
  • Employed an algorithm to correct or exclude implausible LMP-based gestational age estimates using obstetric/clinical data.
  • Calculated sex-specific BWGA means, SDs, and smoothed percentiles (3rd-97th).

Main Results:

  • Included over 7.8 million births, representing 99% of eligible data.
  • The updated reference demonstrated consistent identification of approximately 10% of births at the 10th and 90th percentiles across gestational weeks.
  • Compared to previous references, the new method provided more accurate proportions of infants at extreme BWGA thresholds.

Conclusions:

  • The developed US-based BWGA reference is corrected for gestational age dating inaccuracies.
  • This updated reference enables more precise calculation of categorical and continuous measures of infant size at birth.
  • Facilitates improved clinical assessment and research on birth weight variations.