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Glucose Tolerance and lipid profile changes after surgical menopause
Shahla Yazdani1, Majid Sharbatdaran2, Mohammad Abedi Samakoosh3
1Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences , Babol, Iran. ; Department of Gynacology, Babol University of Medical Sciences, Babol, Iran.
Caspian Journal of Internal Medicine
|April 30, 2014
Summary
Bilateral salpingo-oophorectomy significantly worsens glucose tolerance and lipid profiles, increasing triglycerides, total cholesterol, and LDL. These metabolic changes necessitate careful consideration before ovary removal in premenopausal women.
Area of Science:
- Reproductive Endocrinology
- Metabolic Medicine
- Surgical Outcomes
Background:
- Bilateral salpingo-oophorectomy (BSO) can induce significant metabolic disturbances in women.
- Understanding post-surgical glucose metabolism and lipid profiles is crucial for managing menopausal transition.
Purpose of the Study:
- To evaluate the impact of BSO on glucose tolerance.
- To assess changes in lipid profiles following menopause induced by BSO.
Main Methods:
- 31 premenopausal women (aged 46-52) undergoing BSO for benign conditions were studied.
- Oral glucose tolerance tests (OGTT) and lipid profiles (TG, total cholesterol, LDL, HDL) were measured pre- and post-surgery.
- Insulin levels and HOMA indexes were also assessed.
Main Results:
- A significant increase in 2-hour glucose levels during OGTT was observed post-surgery (P=0.030).
- Lipid profiles showed significant elevations in triglycerides (P=0.005), total cholesterol (P=0.0001), and LDL (P=0.003).
Conclusions:
- BSO leads to adverse changes in glucose tolerance and lipid profiles.
- Increased triglycerides, total cholesterol, and LDL warrant consideration prior to elective BSO in premenopausal women.
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