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Following the Dynamics of Structural Variants in Experimentally Evolved Populations
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Evolutionary constraints in variable environments, from proteins to networks.

Katja M Taute1, Sebastian Gude1, Philippe Nghe1

  • 1FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands.

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Summary
This summary is machine-generated.

Environmental changes influence evolution by altering regulatory networks. New research shows that epistasis, the interaction between mutations, is highly sensitive to environmental shifts, impacting evolutionary trajectories and potential.

Keywords:
epistasisevolutiongenetic interactionsregulatory networksvariable environments

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Area of Science:

  • Evolutionary biology
  • Systems biology
  • Genetics

Background:

  • Environmental changes induce regulatory and evolutionary responses.
  • Understanding the interplay between these responses is crucial for evolutionary insights.

Purpose of the Study:

  • To review recent approaches disentangling regulatory and evolutionary responses to environmental change.
  • To explore how environmental shifts affect evolutionary constraints, particularly epistasis.

Main Methods:

  • Systematic genetic reconstructions in controlled environments.
  • Extension of these methods to more complex environmental systems.

Main Results:

  • Epistasis is significantly altered by environmental changes.
  • Environmental factors profoundly influence the course of evolution by modifying internal constraints.

Conclusions:

  • External environments shape both favored phenotypes and internal evolutionary constraints.
  • New questions arise regarding evolutionary transitions and the evolutionary potential of regulatory networks.