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Low fasting plasma glucose level predicts morbidity and mortality in symptomatic adults with congenital heart disease

Hideo Ohuchi1, Kenji Yasuda1, Shin Ono1

  • 1Department of Pediatric Cardiology and Adult Congenital Heart Disease, National Cerebral and Cardiovascular Center, Osaka, Japan.

International Journal of Cardiology
|May 1, 2014
PubMed

Insights

Low fasting blood glucose (FPG) is common in adults with complex congenital heart disease (ACHD) and predicts hospitalization and mortality in symptomatic patients. This finding is crucial for understanding ACHD prognosis.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Adults with complex congenital heart disease (ACHD) exhibit a high prevalence of abnormal glucose regulation (AGR).
  • The prognostic implications of AGR in ACHD patients remain incompletely understood.

Purpose of the Study:

  • To investigate the prognostic value of abnormal glucose regulation (AGR) in adults with complex congenital heart disease (ACHD).

Main Methods:

  • A 75g oral glucose tolerance test was administered to 438 ACHD patients and 27 healthy controls.
  • Associations between AGR parameters and clinical events (hospitalization, all-cause mortality) were analyzed.

Main Results:

  • Lower fasting blood glucose (FPG) levels were observed in unrepaired and Fontan patients compared to controls.
  • Low FPG (≤ 80 mg/dl) was more prevalent in all ACHD groups than in healthy controls.
  • New York Heart Association class and low FPG independently predicted hospitalization and mortality, while postprandial glucose was not an independent predictor.

Conclusions:

  • Low FPG is a frequent finding in ACHD patients.
  • Low FPG serves as a significant predictor of morbidity and all-cause mortality, particularly in symptomatic ACHD individuals.
Abstract

Keywords:
Adult congenital heart diseaseGlucoseHeart failureMortality

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