[Effect of immunomodulatory therapy on circulatory immune complexes in patients with recurrent depressive disorders]

To study an effect of immunomodulatory therapy with cycloferon on some immunological parameters in patients with depression.

It was examined 192 patients with recurrent depressive disorders. All patients were randomized into two groups -- main group (98 patients) and comparison group (94 patients). Both groups received standard treatment with antidepressants and antipsychotics in ambulatory conditions. Patients of the main group additionally received cycloferon.

Before treatment, there was an increase in concentrations of circulatory immune complexes (CIC), mainly due to most pathogenic average molecular (11S-19S) and small molecular (<11S) fractions, in both groups of the patients. A direct correlation between the degree of the severity of the disease and the degree of changes in immunological parameters was noted.

Inclusion of cycloferon in the complex treatment had a positive effect on immunological parameters and led to the normalization of CIC levels and their fraction content.