Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leprosy: understanding protective immunity.

J D Watson

    Immunology Today
    |July 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Understanding the chemical nature of leprosy (M. leprae) epitopes is a first step. Further research is needed to bridge the gap between immunogenicity and protective immunity for effective leprosy vaccine development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anomalous Nematic States in High Half-Filled Landau Levels.

    Physical review letters·2020
    Same author

    Electron-Hole Asymmetric Chiral Breakdown of Reentrant Quantum Hall States.

    Physical review letters·2016
    Same author

    Optical Emission Spectroscopy Study of Competing Phases of Electrons in the Second Landau Level.

    Physical review letters·2016
    Same author

    T-cell ontogeny: the role of a stimulator - suppressor cell.

    Immunology today·2014
    Same author

    Interleukin 3 and colony-stimulating factors.

    Immunology today·2014
    Same author

    Cytokines and their receptors.

    Immunology today·2014
    Same journal

    Foreword.

    Immunology today·2020
    Same journal

    The origin and significance of anti-DNA antibodies.

    Immunology today·2014
    Same journal

    Mutations of class II MHC molecules.

    Immunology today·2014
    Same journal

    Antigen processing at the molecular level.

    Immunology today·2014
    Same journal

    Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

    Immunology today·2014
    Same journal

    Are MHC class II-restricted cytotoxic T lymphocytes important?

    Immunology today·2014
    See all related articles

    Area of Science:

    • Immunology
    • Vaccine Development
    • Microbiology

    Background:

    • Recombinant proteins are being analyzed as antigens to understand the chemical nature of Mycobacterium leprae (M. leprae) epitopes.
    • The role of these epitopes in protective immunity against leprosy is not yet understood.

    Discussion:

    • Current models for analyzing protective immunity, including mouse footpad infections, immunodeficient mice, armadillos, and primates, have limitations.
    • Only the mouse footpad model has been used to evaluate the protective efficacy of individual antigens.

    Key Insights:

    • There is a significant gap between understanding immunogenicity and protective immunity.
    • Bridging this gap is crucial for the rational design of next-generation leprosy vaccines.

    Related Experiment Videos

    Outlook:

    • Further research is essential to elucidate the role of M. leprae epitopes in protective immunity.
    • Developing effective leprosy vaccines requires a deeper understanding of the relationship between antigenicity and protective immune responses.