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Related Concept Videos

In Vitro Fertilization01:24

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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GnRH antagonist-based protocols for in vitro fertilization.

David Reichman1, Zev Rosenwaks

  • 1Center of Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY, USA, davidreichman.md@gmail.com.

Methods in Molecular Biology (Clifton, N.J.)
|May 1, 2014
PubMed
Summary
This summary is machine-generated.

This chapter details using gonadotropin-releasing hormone (GnRH) antagonists to prevent the luteinizing hormone surge in in vitro fertilization (IVF). It covers practical aspects like dosing, timing, and gonadotropin selection for successful IVF cycles.

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Area of Science:

  • Reproductive endocrinology and infertility treatments.

Background:

  • The luteinizing hormone (LH) surge can prematurely trigger ovulation, compromising in vitro fertilization (IVF) success.
  • Gonadotropin-releasing hormone (GnRH) antagonists offer a method to prevent this endogenous LH surge.

Purpose of the Study:

  • To elaborate on the intricacies of employing GnRH antagonists for preventing the LH surge during IVF.
  • To describe practical aspects of implementing GnRH antagonist-based stimulation protocols.

Main Methods:

  • Discussion of GnRH antagonist implementation in IVF protocols.
  • Elucidation of key protocol parameters including antagonist dosage and timing.
  • Guidance on cycle programming, gonadotropin selection, and final oocyte maturation triggering.

Main Results:

  • Provides a comprehensive overview of GnRH antagonist use in IVF.
  • Details critical factors for successful antagonist protocol initiation and management.
  • Offers insights into optimizing ovarian stimulation and oocyte retrieval.

Conclusions:

  • GnRH antagonist protocols are a viable strategy for controlling the ovulatory surge in IVF.
  • Careful consideration of dosing, timing, and associated medications is crucial for efficacy.
  • This chapter serves as a practical guide for clinicians implementing these protocols.