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Urinary nerve growth factor levels could be a biomarker for overactive bladder symptom: a meta-analysis
1Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Genetics and Molecular Research : GMR
|May 1, 2014
Summary
Urinary nerve growth factor (uNGF) is a potential biomarker for diagnosing overactive bladder (OAB) symptoms and differentiating subtypes. Elevated uNGF levels decreased significantly after successful OAB treatment.
Area of Science:
- Urology
- Biomarkers
- Nephrology
Background:
- Overactive bladder (OAB) is a common condition impacting quality of life.
- Identifying reliable biomarkers for OAB diagnosis and management is crucial.
- Urinary nerve growth factor (uNGF) has been proposed as a potential diagnostic marker.
Purpose of the Study:
- To evaluate the utility of urinary nerve growth factor (uNGF) as a biomarker for overactive bladder (OAB) symptoms.
- To assess uNGF's role in differentiating OAB subtypes and predicting treatment response.
- To investigate uNGF's potential in distinguishing OAB from interstitial cystitis/painful bladder syndrome (IC/PBS).
Main Methods:
- A comprehensive meta-analysis was conducted on 8 case-control studies.
- Studies compared uNGF levels in patients with OAB versus healthy controls.
- Subgroup analyses examined OAB subtypes (wet/dry) and compared with IC/PBS.
Main Results:
- Patients with OAB consistently showed higher uNGF levels than healthy individuals.
- Successful OAB treatment led to a significant reduction in uNGF levels.
- OAB-wet patients exhibited higher uNGF levels than OAB-dry patients.
- No significant difference in uNGF/Cr levels was observed between OAB and IC/PBS patients.
Conclusions:
- uNGF shows promise as a biomarker for OAB diagnosis and subtype differentiation (wet vs. dry).
- uNGF may serve as a predictive biomarker for treatment efficacy in OAB.
- uNGF is not suitable for differentiating OAB from IC/PBS based on current evidence.
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