Association between polymorphism of β3-adrenoceptor gene and overactive bladder: a meta-analysis

Area of Science:

• Genetics
• Urology
• Pharmacology

Background:

• Genetic variations in the human beta-3 adrenoceptor (β3-AR) gene influence bladder muscle function.
• The Trp64Arg polymorphism in the β3-AR gene is implicated in overactive bladder (OAB) development.
• Previous studies on the association between this polymorphism and OAB risk have yielded controversial results.

Purpose of the Study:

• To conduct a meta-analysis to investigate the association between the β3-AR Trp64Arg polymorphism and the risk of developing overactive bladder (OAB).

Main Methods:

• A meta-analysis was performed on 2 case-control studies.
• The analysis included a total of 149 OAB cases and 270 healthy controls.
• Examined the association between the Trp64Arg polymorphism and OAB susceptibility.

Main Results:

• The Arg allele of the β3-AR gene was found to be positively associated with OAB susceptibility.
• Individuals carrying the Arg allele (Trp64Arg and Arg64Arg genotypes) showed a positive association with OAB.
• The Trp64Arg polymorphism is implicated in the pathogenesis of OAB.

Conclusions:

• The β3-AR Trp64Arg polymorphism plays a role in the development of overactive bladder.
• The Arg allele and its carriers are associated with an increased risk of OAB.
• This meta-analysis provides evidence supporting the involvement of β3-AR genetic variations in OAB pathogenesis.