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VEGF modulates synaptic activity in the developing spinal cord.

Sylvaine Guérit1, Anne-Emilie Allain, Céline Léon

  • 1Université Bordeaux, Angiogenesis and Tumor Microenvironment Laboratory, F-33615 Pessac Cedex France; INSERM, Angiogenesis and Tumor Microenvironment Laboratory, F-33615 Pessac Cedex, France.

Developmental Neurobiology
|May 1, 2014
PubMed
Summary
This summary is machine-generated.

Vascular endothelial growth factor (VEGF) enhances inhibitory synaptic activity in developing spinal neurons. This study reveals a novel role for VEGF in modulating neuronal development and synapse formation.

Keywords:
angiogenic factorsdevelopmentneuronal activityvascular endothelial growth factor

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Vascular Biology

Background:

  • The nervous and vascular systems exhibit developmental and pathological interconnections, yet specific interactions remain unclear.
  • Vascular Endothelial Growth Factor (VEGF) is a critical regulator of blood vessel development.
  • The precise influence of VEGF on neuronal development is not well-defined.

Purpose of the Study:

  • To investigate the role of VEGF in modulating neuronal developmental processes.
  • To determine if VEGF affects synaptic activity and excitability in embryonic spinal motoneurons.
  • To explore the developmental timing and molecular mechanisms of VEGF's action on neurons.

Main Methods:

  • Electrophysiological recordings of synaptic activity in embryonic spinal motoneurons.
  • Manipulation of VEGF levels (enhancement and blockade) during specific developmental windows.
  • Assessment of neurotransmitter transporter density (vesicular inhibitory amino acid transporter).
  • Inhibition of specific VEGF receptors.

Main Results:

  • VEGF significantly enhanced gamma-aminobutyric acid (GABA)/glycinergic synaptic activity frequency, but not amplitude, in spinal motoneurons.
  • VEGF did not alter motoneuron excitability.
  • The observed effects of VEGF were restricted to early embryonic stages (E13.5-E15.5) and diminished by E17.5.
  • VEGF increased the density of the vesicular inhibitory amino acid transporter at the motoneuron membrane.
  • Blocking endogenous VEGF reversed these effects, decreasing synaptic event frequency.

Conclusions:

  • VEGF acts as a modulator of neuronal activity during synapse formation, specifically enhancing inhibitory neurotransmission.
  • This study identifies a novel ontogenic role for the angiogenic factor VEGF in the developing nervous system.
  • VEGF's influence on neuronal development is stage-specific and mediated through mechanisms affecting vesicular transporter density.