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Invasive micropapillary carcinoma: a distinct type of adenocarcinomas in the gastrointestinal tract

Katarzyna Guzińska-Ustymowicz1, Katarzyna Niewiarowska1, Anna Pryczynicz1

  • 1Katarzyna Guzińska-Ustymowicz, Katarzyna Niewiarowska, Anna Pryczynicz, Department of General Pathomorphology, Medical University of Bialystok, 15-269 Bialystok, Poland.

World Journal of Gastroenterology
|May 1, 2014
PubMed

Insights

Invasive micropapillary carcinoma (IMPC), a rare tumor type, is increasingly found in the gastrointestinal tract. This review details its characteristics and immunohistological identification in GI cancers.

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Invasive micropapillary carcinoma (IMPC) is a rare histological tumor type.
  • Initially described in breast cancer, IMPC is now identified in various organs, including the gastrointestinal (GI) tract.
  • IMPC is characterized by neoplastic cell clusters in empty spaces, lacking a fibrous-vascular core and exhibiting reverse polarity.

Purpose of the Study:

  • To characterize invasive micropapillary carcinoma in the GI tract (colon, rectum, stomach, etc.).
  • To determine the immunohistological identification methods for IMPC in these locations.

Main Methods:

  • Literature review of invasive micropapillary carcinoma in GI cancers.
  • Analysis of histological and immunohistological features of IMPC.

Main Results:

  • IMPC in the GI tract is associated with lymph node metastasis and lymphovascular invasion.
  • IMPC exhibits "inside-out" structures due to reverse polarity, impacting adhesion and malignancy grade.
  • IMPC can serve as a prognostic factor for disease-free and overall survival in GI cancers.

Conclusions:

  • Invasive micropapillary carcinoma is a distinct histological entity within GI malignancies.
  • Understanding IMPC's characteristics and immunohistological markers is crucial for diagnosis and prognosis.
  • Further research into IMPC in the GI tract may improve patient outcomes.
Keywords:
Invasive micropapillary carcinomaLymph node metastasesMUC-1

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