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Anti-rods and rings autoantibodies can occur in the hepatitis c-naïve population

Y Shaikh, A Krantz, Y El-Farra

    Journal of Preventive Medicine and Hygiene
    |May 3, 2014
    PubMed
    Abstract

    Insights

    The anti-Rods and Rings autoantibody, previously linked to hepatitis C treatment, is present in the general population. Most individuals with this autoantibody show no history of hepatitis C infection, suggesting alternative causes.

    Area of Science:

    • Immunology
    • Epidemiology
    • Autoimmunity

    Background:

    • The anti-Rods and Rings autoantibody is associated with hepatitis C treatment, particularly involving CTP and GTP synthetic pathway inhibitors.
    • Its presence may impact therapeutic response, necessitating further investigation into its origins.

    Purpose of the Study:

    • To determine the epidemiology of the anti-Rods and Rings autoantibody in the general, non-clinical population.
    • To investigate the prevalence and demographic distribution of anti-RR autoantibodies.

    Main Methods:

    • Cross-sectional study utilizing the National Health and Nutrition Examination Survey (NHANES) data.
    • Immunofluorescence assays were performed by NHANES laboratories.
    • Prevalence and distribution were calculated using sample weights, with a medication profile constructed for positive cases.

    Main Results:

    • The study analyzed 4738 individuals over 12 years old.
    • Anti-Rods and Rings autoantibodies were detected in 39 individuals, representing 1.3 million people in the US.
    • Of those positive, 38 had no history of hepatitis C virus infection, and most reported polypharmacy.

    Conclusions:

    • This study is the first to demonstrate the occurrence of anti-Rods and Rings autoantibodies in the general population without hepatitis C virus infection.
    • The findings suggest potential alternative etiologies for anti-RR autoantibodies beyond hepatitis C virus infection and its treatment.
    • Further research is needed to identify these alternative causes.

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