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Acute accidental lindane ingestion in toddlers
S E Aks1, A Krantz, D O Hryhrczuk
1Toxikon Consortium Cook County Hospital, University of Illinois Hospital, Rush-Presbyterian-St Luke's Medical Center, USA.
Annals of Emergency Medicine
|November 1, 1995
Summary
Lindane ingestion toxicity is rare but serious. This study analyzes ingestion cases, comparing blood levels and toxicity signs to guide emergency physicians in preventing acute lindane poisoning.
Area of Science:
- Toxicology
- Dermatology
- Pharmacokinetics
Background:
- Lindane (gamma-hexachlorocyclohexane) is a topical medication historically used for scabies and lice.
- Dermal exposure is the most common route for lindane toxicity.
- Acute lindane poisoning via ingestion is infrequently reported, especially with documented blood levels.
Observation:
- Presents three rare cases of significant lindane ingestion.
- Analyzes blood lindane levels and their elimination half-lives in these cases.
- Correlates observed blood levels with clinical signs and symptoms of lindane toxicity.
Findings:
- Ingestion cases reveal variable blood lindane half-lives.
- Toxicity manifestations are linked to peak blood concentrations and duration of exposure.
- Comparison with literature data highlights the challenges in predicting toxicity solely based on blood levels.
Implications:
- Emergency physicians should be aware of the potential for severe toxicity from lindane ingestion.
- Patient education on correct lindane application is crucial to prevent accidental ingestion.
- Consideration of alternative, less toxic scabicidal agents is recommended to minimize poisoning risks.
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