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Infective endocarditis associated with mitral valve prolapse in a patient with Klinefelter syndrome

Yasushi Ueki1, Atsushi Izawa, Souichiro Ebisawa

  • 1Department of Cardiovascular Medicine, Shinshu University School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|May 3, 2014
PubMed

Insights

This case report details infective endocarditis in a patient with Klinefelter syndrome and mitral valve prolapse (MVP). Early diagnosis and surgical intervention were crucial for managing this severe cardiovascular complication.

Area of Science:

  • Cardiology
  • Genetics
  • Infectious Diseases

Background:

  • Klinefelter syndrome is associated with cardiovascular abnormalities, including mitral valve prolapse (MVP).
  • Infective endocarditis is a serious infection that can affect heart valves.

Observation:

  • A 34-year-old male with Klinefelter syndrome presented with prolonged fever and headache.
  • Echocardiography revealed severe mitral regurgitation due to a large vegetation on a prolapsed mitral valve.

Findings:

  • Blood cultures identified Streptococcus oralis as the causative agent.
  • Surgical mitral valve plasty was performed due to vegetation size (>10 mm) and embolic risk.

Implications:

  • This case highlights a potential link between Klinefelter syndrome and MVP.
  • Emphasizes the need for cardiovascular screening in Klinefelter syndrome patients.
  • Underscores the importance of endocarditis prevention and prompt management in this population.

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