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Pyrophosphate Scintigraphy Changes After Tafamidis Therapy - Proposed Novel Index From Quantitative Single-Photon
Tsuneaki Yoshinaga1,2, Shin Yanagisawa3, Masatoshi Minamisawa4,5
1Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine.
Background:
Because a disease-modifying therapy is now available, bone scintigraphy plays a crucial role in diagnosing transthyretin cardiac amyloidosis (ATTR-CM).
Methods And Results:
We retrospectively analyzed 24 patients with ATTR-CM to determine the amyloid accumulation volume (AAV: mean standardized uptake value×volume) of the left ventricular wall. AAV showed a significant decrease (591.1±426.0 vs. 213.8±201.9, P<0.0001) after tafamidis treatment, and correlated with troponin T (R=0.49, P=0.022).
Conclusions:
AAV provided a precise quantitative evaluation of the amyloid burden in ATTR-CM.
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