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Translating intracellular calcium signaling into models.
1School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Cold Spring Harbor Protocols
|May 3, 2014
Summary
This review covers key milestones in intracellular calcium signaling models, focusing on calcium-induced calcium release (CICR) mechanisms. Models offer insights into calcium signal machinery and local-to-global pattern contributions.
Area of Science:
- Cellular Biology
- Biophysics
- Computational Biology
Background:
- Extensive experimental data on intracellular calcium levels.
- 25 years of developing numerous modeling frameworks for calcium signaling.
Purpose of the Study:
- Review milestones in intracellular calcium modeling.
- Emphasize calcium-induced calcium release (CICR) via IP3 and RyR receptors.
- Highlight challenges in translating calcium signal understanding into models.
Main Methods:
- Review of existing literature on intracellular calcium modeling.
- Focus on models of calcium-induced calcium release (CICR).
- Analysis of how key CICR features are represented in models.
Main Results:
- Successful models provide mechanistic insights into calcium signaling.
- Models elucidate the contribution of local calcium release to global patterns.
- Identified challenges in computational modeling of calcium dynamics.
Conclusions:
- Intracellular calcium modeling is crucial for understanding cellular signaling.
- Models offer insights beyond current experimental resolution.
- Further development is needed to bridge experimental and theoretical understanding of calcium signals.
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