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Updated: Apr 30, 2026

Reliable and High Efficiency Extraction of Kidney Immune Cells
Published on: August 19, 2016
The heterogeneous mononuclear phagocyte system of the kidney
Kevin J Woollard1, Charles D Pusey1
1Department of Medicine, Imperial College London, London, UK.
Abstract:
The kidney has a diverse repertoire of cells that make up the mononuclear phagocyte system (MPS). Wu et al. identify a population of CD8αα+CD11c+MHC-II+ blood precursors that display dendritic cell-like characteristics in the glomeruli. These cells show increased recruitment in a rat anti-glomerular basement membrane glomerulonephritis model and were able to attenuate disease. This study highlights the importance of the MPS in kidney disease and the need to better understand it to develop immunotherapeutics translatable to the renal patient.
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