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Phyllodes tumor of the prostate: a case report
1Department of Pathology, Hiroshima University School of Medicine.
Japanese Journal of Clinical Oncology
|September 1, 1989
Summary
A rare benign prostatic phyllodes tumor with fibroblastic differentiation was found in a 78-year-old man. This estrogen-dependent tumor showed no recurrence five years post-surgery.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Prostatic phyllodes tumors are rare neoplasms.
- Understanding their histological and molecular characteristics is crucial for diagnosis and management.
Observation:
- A case report of a prostatic phyllodes tumor in a 78-year-old male patient.
- Histological examination revealed myxomatous and cellular areas with atypical stromal cells, occasional multinucleated giant cells, and rare mitoses.
Findings:
- Tumor cells demonstrated fibroblastic differentiation, confirmed by electron microscopy (abundant rough endoplasmic reticulum, free ribosomes) and vimentin immunoreactivity.
- Estrogen receptor (ER) immunoreactivity was observed in approximately one-third of the tumor cells, suggesting an estrogen-dependent nature.
- The patient remained disease-free five years after surgical resection, indicating a benign clinical course.
Implications:
- This case highlights the potential for benign prostatic phyllodes tumors to exhibit fibroblastic differentiation and estrogen dependency.
- The findings contribute to the understanding of rare prostatic tumors and may inform future treatment strategies.
- Long-term follow-up is essential for patients with prostatic phyllodes tumors to monitor for recurrence.