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Detection and genetic characterization of cosavirus in a pediatric patient with diarrhea

Pattara Khamrin1, Niwat Maneekarn

  • 1Department of Microbiology, Faculty of Medicine, Chiang Mai University, 110 Intawarorose, Sriphoom, Muang, Chiang Mai, 50200, Thailand.

Archives of Virology
|May 3, 2014
PubMed

Insights

Human cosavirus (HCoSV) was detected in a child with diarrhea in Thailand, marking the first pediatric case in the region. This finding suggests a shared evolutionary origin for HCoSV strains in Thailand and China.

Area of Science:

  • Virology
  • Molecular Biology
  • Public Health

Background:

  • Human cosavirus (HCoSV), a member of the Picornaviridae family, is a recently identified virus.
  • Acute gastroenteritis remains a significant health concern in pediatric populations worldwide.

Observation:

  • A study screened 411 fecal samples from children with acute gastroenteritis in Thailand.
  • Human cosavirus (HCoSV) was identified in one pediatric patient using RT-nested PCR.

Findings:

  • This case represents the first documented HCoSV infection in a child with diarrhea in Thailand.
  • Phylogenetic analysis indicated the Thai HCoSV strain belongs to genotype A6, closely related to Chinese strains.
  • The genetic similarity suggests a common evolutionary ancestor for HCoSV strains in Thailand and China.

Implications:

  • The findings highlight the presence of HCoSV in Thailand and its potential role in pediatric gastroenteritis.
  • Further research is crucial to determine the prevalence, genetic diversity, and clinical significance of HCoSV.
  • Understanding HCoSV epidemiology is essential for public health strategies and disease prevention.

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