[Simulation of the action of ion channel blockaders on post-synaptic currents]

Numerical model showing action of open channel blockers on the neuromuscular junction is described. Quantitative aspects of the simple blocking action are analyzed and criteria which allow discriminating between channel blocking action and channel kinetics modification are suggested. The results of simulation are compared with experimental data. Some peculiarities of channel blocking drug action after acetylcholinesterase inhibition are discussed.