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Updated: Feb 16, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Status epilepticus induced by pentylenetetrazole increases short-term synaptic facilitation in the hippocampus of
T Yu Postnikova1,2, A M Trofimova1,2, A V Zaitsev3
1Sechenov Institute of Evolutionary Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Abstract:
We studied the effect of status epilepticus (SE) on short-term synaptic plasticity. The amplitudes of field potentials in response to extracellular stimulation of the Schaffer collaterals were recorded in hippocampal slices. Subtle modifications were revealed on day 1 after SE, whereas on days 3 and 7 we did not find any differences from the control. These data show that, one day after SE, the probability of a transmitter release in hippocampal synapses decreases that serves as a compensatory mechanism, which prevents seizure activity.
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