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The HIV-Brazil cohort study: design, methods and participant characteristics

Alexandre Grangeiro1, Maria Mercedes Escuder2, Alex Jones Flores Cassenote

  • 1Department of Preventive Medicine, University of São Paulo School of Medicine, São Paulo, Brazil.

Plos One
|May 3, 2014
PubMed

Insights

The HIV-Brazil Cohort Study tracked over 5,000 adults on combination antiretroviral therapy (cART), revealing treatment effectiveness and impacts on health outcomes in Brazil. Findings highlight viral suppression rates and mortality among HIV patients receiving cART.

Area of Science:

  • Clinical Medicine
  • Infectious Diseases
  • Public Health

Background:

  • The HIV-Brazil Cohort Study was initiated to evaluate combination antiretroviral therapy (cART) effectiveness.
  • The study aimed to assess cART's impact on morbidity, quality of life (QOL), and mortality in HIV-infected adults.
  • It described the study design, patient profiles, and cART initiation characteristics from 2003 to 2010.

Purpose of the Study:

  • To analyze the effectiveness of combination antiretroviral therapy (cART) in a large Brazilian cohort.
  • To determine the impact of cART on morbidity, quality of life (QOL), and mortality among HIV-infected individuals.
  • To characterize patient profiles and cART initiation patterns in a real-world setting.

Main Methods:

  • Longitudinal cohort study following 5,061 HIV-infected adults initiating cART between 2003 and 2010.
  • Data collected from routine clinical care, national information systems, and self-reported QOL questionnaires.
  • Key outcomes included HIV-related diseases, viral suppression, treatment failures, and mortality.

Main Results:

  • Median follow-up was 4.1 years with an 83.4% retention rate.
  • Patients were predominantly men (63%), with a mean age of 36.9 years; 55.2% acquired HIV heterosexually.
  • 77.4% achieved viral suppression within 12 months; 45.4% had HIV-related manifestations post-cART initiation; AIDS mortality was 13.9 per 1,000 person-years.

Conclusions:

  • Results from cART in daily practice are crucial for low- and middle-income countries.
  • The HIV-Brazil Cohort Study's scope and patient profile reflect the national AIDS epidemic, providing valuable insights.
  • This study contributes to understanding cART effectiveness and outcomes in a real-world setting.
Abstract

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