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Updated: Apr 30, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Small cell lung carcinoma associated with progressive systemic sclerosis.
Kaushik Saha1, Arnab Saha1, Prabodh Panchadhyayee1
1Department of Pulmonary Medicine, Burdwan Medical College, Burdwan, West Bengal, India.
This case report highlights a rare instance of small cell lung cancer (SCLC) in a patient with progressive systemic sclerosis (PSS). Early diagnosis and chemotherapy led to patient improvement.
Area of Science:
- Pulmonology
- Oncology
- Rheumatology
Background:
- Progressive systemic sclerosis (PSS) is rarely associated with malignancy.
- Small cell lung cancer (SCLC) is an exceptionally rare lung malignancy in PSS patients.
Observation:
- A 55-year-old non-smoking female with a one-year history of PSS presented with cough, dyspnea, and unilateral edema.
- Imaging revealed a right upper lobe lung mass, bilateral pleural effusion, and interstitial lung disease consistent with non-specific interstitial pneumonia.
- CT-guided fine needle aspiration cytology confirmed SCLC.
Findings:
- The patient was diagnosed with small cell lung cancer (SCLC) in the context of progressive systemic sclerosis (PSS).
- Treatment with carboplatin and etoposide chemotherapy resulted in clinical improvement.
Implications:
- This case underscores the importance of considering rare malignancies in PSS patients.
- Prompt diagnosis and treatment of SCLC in PSS can lead to favorable outcomes.
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