Related Experiment Video

Updated: Apr 30, 2026

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
07:59

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Published on: September 10, 2021

5.8K

Human Bocavirus in Iranian children with acute gastroenteritis

Seyed Hamidreza Monavari1, Samileh Noorbakhsh2, Hamidreza Mollaie3

  • 1PhD, Associate professor, Department of Virology and Anti-Microbial Resistance Research Center, Tehran University of Medical Sciences, Hemmat Highway, Tehran, Iran. hrmonavari@yahoo.com.

Medical Journal of the Islamic Republic of Iran
|May 3, 2014
PubMed

Insights

Human Bocavirus (HBoV) is prevalent in Iranian children with acute gastroenteritis. This study suggests HBoV plays a role in the pathogenesis of gastroenteritis in young children.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Human Bocavirus (HBoV) is globally distributed.
  • Evidence suggests HBoV is pathogenic to the human gastrointestinal tract.
  • Limited data exists on HBoV's role in gastroenteritis.

Purpose of the Study:

  • To determine the prevalence of HBoV in children diagnosed with gastroenteritis.
  • To investigate the association between HBoV and acute gastroenteritis in a pediatric population.

Main Methods:

  • Real-time PCR TaqMan assay used for HBoV detection.
  • 200 stool specimens were analyzed.
  • Samples were collected in viral transport media.

Main Results:

  • 16 out of 200 stool samples (8%) tested positive for HBoV.
  • HBoV was detected in children aged 1-5 years with acute gastroenteritis.
  • A statistically significant association was found between HBoV and gastroenteritis (p=0.0001).

Conclusions:

  • Human Bocavirus shows a high prevalence in young children with acute gastroenteritis in Iran.
  • HBoV is implicated as a potential causative agent in the pathogenesis of gastroenteritis.
Abstract

Keywords:
ChildGastroenteritisHuman BocavirusReal-time PCR

More Related Videos

Swab Sampling Method for the Detection of Human Norovirus on Surfaces10:03

Swab Sampling Method for the Detection of Human Norovirus on Surfaces

Published on: February 6, 2017

19.6K
Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

16.9K

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
88
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
25
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
59
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
86
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...
47