Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Targeted Cancer Therapies

Targeted Cancer Therapies

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genomic drivers of brain metastases in lung cancer.

Neuro-oncology advances·2026

Same author

Association of Lipid and Inflammatory Profiles With Tumor Stage in Hepatocellular Carcinoma.

Cancer medicine·2026

Same author

Data subdivision approach enhances machine learning-based mortality prediction in pediatric ICU patients.

PloS one·2026

Same author

Light-Inducible Bispecific DNAzymes Reveal Mitochondrial Fe<sup>2+</sup>/Fe<sup>3+</sup> Dynamics During Ferroptosis.

Angewandte Chemie (International ed. in English)·2026

Same author

A Cell-Resolved Ultrastable Biosensor Enables One-Step Detection of Gene-Fusion Transcripts in Unprocessed Whole Blood.

Angewandte Chemie (International ed. in English)·2026

Same author

Comparison of the clinical efficacy of different acupuncture methods in the treatment of post-stroke central facial paralysis-a network meta-analysis based on randomized controlled trials.

Frontiers in neurology·2026

Search research articles

Related Experiment Video

Updated: Apr 30, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

DNA Aptamer Technology for Personalized Medicine.

Hang Xing¹, Kevin Hwang², Ji Li¹

¹Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 ; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.

Current Opinion in Chemical Engineering

|May 3, 2014

Summary

This review covers DNA aptamers for personalized medicine, focusing on in vivo studies and applications in diagnostics and therapeutics for diseases like cancer. DNA aptamer technology shows promise for advancing personalized medicine.

Keywords:

DNA aptamer cancer diagnosis personalized medicine targeted delivery therapy

More Related Videos

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

Related Experiment Videos

Last Updated: Apr 30, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

Area of Science:

Biotechnology
Molecular Biology
Nanotechnology

Background:

DNA aptamers are emerging as powerful tools in personalized medicine.
Recent advancements focus on in vivo applications and integration with other technologies.

Purpose of the Study:

To review the latest developments in DNA aptamer technology for personalized medicine.
To highlight in vivo studies and diverse applications including diagnostics, therapeutics, and drug delivery.

Main Methods:

Review of recent scientific literature on DNA aptamers.
Analysis of studies involving DNA nanostructures, nanomaterials, and microfluidic devices.
Examination of aptamer applications in cancer and other diseases.

Main Results:

DNA aptamers are being developed as diagnostic probes and therapeutic agents.
Combinations of aptamers with nanostructures, nanomaterials, and microfluidics enhance their utility.
Aptamers show potential as targeting agents in drug delivery systems.

Conclusions:

DNA aptamer technology offers significant advantages for personalized medicine.
Further in vivo studies and technological integration are crucial for clinical translation.
Continued development holds promise for advancing targeted therapies and diagnostics.