Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do cortical areas emerge from a protocortex?

D D O'Leary

    Trends in Neurosciences
    |October 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    The developing mammalian neocortex, or protocortex, is initially uniform. Post-neurogenesis modifications lead to the emergence of distinct neocortical areas, raising questions about predetermined development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Altered hormonal regulation and blood flow distribution with cardiovascular deconditioning after short-duration head down bed rest.

    Journal of applied physiology (Bethesda, Md. : 1985)·2007
    Same author

    Heterogeneity of responses to orthostatic stress in homozygous twins.

    Journal of applied physiology (Bethesda, Md. : 1985)·2006
    Same author

    Splanchnic and peripheral vascular resistance during lower body negative pressure (LBNP) and tilt.

    Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2005
    Same author

    Test-retest repeatability of muscle sympathetic nerve activity: influence of data analysis and head-up tilt.

    Autonomic neuroscience : basic & clinical·2004
    Same author

    Optimizing an LBNP protocol to test cardiopulmonary and arterial baroreflex control of vascular resistance.

    Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2004
    Same author

    Differential effect of head-up tilt on cardiovagal and sympathetic baroreflex sensitivity in humans.

    Experimental physiology·2003
    Same journal

    Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

    Trends in neurosciences·2026
    Same journal

    Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

    Trends in neurosciences·2026
    Same journal

    From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

    Trends in neurosciences·2026
    Same journal

    Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

    Trends in neurosciences·2026
    Same journal

    A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

    Trends in neurosciences·2026
    Same journal

    Exercise as a regulator of glymphatic function.

    Trends in neurosciences·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Developmental Biology

    Background:

    • The adult mammalian neocortex exhibits distinct areas based on cytoarchitecture and connections.
    • The developing neocortex (protocortex) is initially more uniform and undifferentiated.

    Purpose of the Study:

    • To investigate the extent to which neocortical areas are predetermined during development.
    • To examine the processes of neocortical area generation and subsequent parcellation.

    Main Methods:

    • Review of recent findings on neocortex development.
    • Analysis of the transition from a uniform protocortex to distinct areal specializations.

    Main Results:

    • Neocortical areas emerge through significant modifications after the primary neurogenesis phase.

    Related Experiment Videos

  • The protocortex undergoes substantial changes to form well-defined areas.

    • Conclusions:

    • Neocortical area formation involves substantial post-neurogenesis modifications.
    • The degree of predetermination for specific neocortical areas requires further investigation.