Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Divisions of the Nervous System01:23

Functional Divisions of the Nervous System

17.2K
The nervous system, responsible for sensing, integrating, and responding to various stimuli, is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The PNS has two functional divisions: the sensory or afferent division and the motor or efferent division.
The sensory division transmits information from sensory receptors in the body to the CNS. It provides the CNS with knowledge about somatic senses (such as tactile, thermal, pain, and proprioceptive sensations)...
17.2K
Decision Making01:20

Decision Making

1.2K
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
1.2K
Reason and Intuition01:37

Reason and Intuition

5.9K
The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the...
5.9K
Decision Making: Traditional Method01:14

Decision Making: Traditional Method

4.4K
The process of hypothesis testing based on the traditional method includes calculating the critical value, testing the value of the test statistic using the sample data, and interpreting these values.
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
4.4K
Nervous Tissue: Neuron Types01:19

Nervous Tissue: Neuron Types

7.7K
Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
7.7K
Organization of the Nervous System01:13

Organization of the Nervous System

12.9K
The nervous system is one of the most complex systems in our body. It is organized into two main divisions: the central nervous system (CNS) and the peripheral nervous system (PNS).
The CNS, comprising the brain and spinal cord, houses billions of neurons. The brain is housed in the skull, while the spinal cord is linked to the brain through the foramen magnum of the occipital bone and is surrounded by the protective structure of the vertebral column. It is responsible for processing various...
12.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative ASCL1 interactome analysis reveals CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified neuroblastoma.

Molecular cancer research : MCR·2026
Same author

Neuroblastoma cell lines display heterogeneity in differentiation responses.

Wellcome open research·2025
Same author

CDK4/6 inhibitors display a class effect in inducing differentiation of neuroblastoma cells.

Wellcome open research·2025
Same author

Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1.

Open biology·2025
Same author

Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific.

Development (Cambridge, England)·2025
Same author

Phospho-regulation of ASCL1-mediated chromatin opening during cellular reprogramming.

Development (Cambridge, England)·2024
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

5.4K

Nervous decision-making: to divide or differentiate.

Laura J A Hardwick1, Anna Philpott1

  • 1Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.

Trends in Genetics : TIG
|May 6, 2014
PubMed
Summary
This summary is machine-generated.

Cell division and differentiation are crucial for central nervous system (CNS) development. This review details the complex interplay between cell cycle changes and differentiation, offering new insights into their coordination.

Keywords:
cell cycledifferentiationneurogenesis

More Related Videos

From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data
12:08

From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data

Published on: August 13, 2014

24.9K
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
07:42

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Published on: August 2, 2018

14.2K

Related Experiment Videos

Last Updated: Apr 30, 2026

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

5.4K
From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data
12:08

From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data

Published on: August 13, 2014

24.9K
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
07:42

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

Published on: August 2, 2018

14.2K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The development of the central nervous system (CNS) relies on a precise balance between cell proliferation and differentiation.
  • The decision for a neural progenitor cell to divide or differentiate dictates the number and type of neurons and glia formed, shaping CNS structure and function.
  • Understanding this balance is key to comprehending normal brain development and potential disorders.

Purpose of the Study:

  • To review the fundamental importance of the proliferation-differentiation balance in CNS development.
  • To explore the bidirectional links coordinating cell cycle regulation and differentiation.
  • To highlight recent advances in understanding the mechanistic basis of these interactions.

Main Methods:

  • Literature review focusing on recent advances in the field.
  • Analysis of studies investigating cell cycle changes during neural differentiation.
  • Synthesis of findings on transcriptional, post-translational, and epigenetic regulatory mechanisms.

Main Results:

  • Significant progress has been made in characterizing cell cycle modifications during differentiation.
  • Multiple bidirectional regulatory links between cell cycle progression and differentiation have been identified.
  • New insights reveal complex interactions at transcriptional, post-translational, and epigenetic levels.

Conclusions:

  • The intricate coordination between cell proliferation and differentiation is essential for proper CNS development.
  • Understanding these molecular links provides a foundation for future research into neurodevelopmental processes.
  • Further investigation into these mechanisms can inform therapeutic strategies for CNS disorders.