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Updated: Apr 30, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Epidemiologic trends in head and neck cancer and aids in diagnosis
Nadarajah Vigneswaran1, Michelle D Williams2
1Oral and Maxillofacial Pathology Biopsy Service, The University of Texas School of Dentistry at Houston, 1941 East Road BBSB, Room 5320, Houston, TX 77054, USA.
Abstract:
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide predominately associated with tobacco use. Changing cause and increased incidence in oropharyngeal carcinomas is associated with high-risk types of human papilloma virus and has an improved survival. Optical devices may augment visual oral examination; however, their lack of specificity still warrants tissue evaluation/biopsy. Histologic factors of oral carcinomas are critical for patient management and prognostic determination. Clinical biomarkers are still needed to improve early detection, predict malignant transformation, and optimize therapies.
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