Related Experiment Video
Updated: Apr 30, 2026

Assay for Adhesion and Agar Invasion in S. cerevisiae
Published on: November 8, 2006
A cyclin-like protein, ClgA, regulates development in Aspergillus nidulans
Zhenzhong Yu1, Menghao Cai1, Wei Hu1
1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Abstract:
A cyclin-like protein from Aspergillus nidulans, ClgA, was identified. Its cyclin-like subunit shares 28.3% identity to Saccharomyces cerevisiae Clg1. Deletion of clgA slightly influenced fungal growth, but repressed asexual development and made it more sensitive to temperature variations. It also downregulated expression of brlA, abaA and wetA, which are critically responsible for asexual development. Sexual development was impaired in the ΔclgA mutant. Its related genes, veA and nosA, were expressed weakly in the ΔclgA mutant, while nsdD expression showed the opposite behavior. Generally, ClgA functioned differently from other reported cyclins in development of A. nidulans.
Related Concept Videos
Anaphase Promoting Complex
Anaphase Promoting Complex
Positive Regulator Molecules
Positive Regulator Molecules
The Cell Cycle Control System
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
The Cell Cycle Control System

