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Engineering and evaluating drug delivery particles in microfluidic devices.

Mattias Björnmalm1, Yan Yan1, Frank Caruso1

  • 1Department of Chemical and Biomolecular Engineering, The University of Melbourne, Melbourne, Victoria 3010, Australia.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 6, 2014
PubMed
Summary
This summary is machine-generated.

Microfluidics enables precise engineering of drug delivery particles and creation of advanced in vitro models. This technology enhances understanding of particle performance for improved drug delivery systems.

Keywords:
In vitro/in vivo modelMicrofluidicsNanomedicineNanoparticles

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Area of Science:

  • Biotechnology
  • Materials Science
  • Pharmacology

Background:

  • Particle-based drug delivery requires high-fidelity particle engineering and understanding of biological performance.
  • Microfluidics offers precise control over microscale environments for particle fabrication and biological evaluation.

Purpose of the Study:

  • To review the application of microfluidics in addressing key challenges in particle-based drug delivery.
  • To highlight how microfluidic devices facilitate particle engineering and the development of in vitro models.

Main Methods:

  • Discussion of microfluidic device design for controlled interfacial engineering of particles.
  • Overview of microfluidic systems for establishing dynamic in vitro models mimicking in vivo conditions.
  • Exploration of modular microfluidic devices for creating complex biological models.

Main Results:

  • Microfluidics enables precise control over particle interfaces, leading to high-fidelity particle engineering.
  • Microfluidic devices can create dynamic in vitro models for studying particle-biological interactions.
  • Development of increasingly realistic multi-cell, multi-tissue, and multi-organ models is facilitated by microfluidics.

Conclusions:

  • Microfluidics is a powerful tool for advancing particle-based drug delivery through enhanced engineering and biological evaluation.
  • Commercialization of microfluidic tools presents new opportunities for drug delivery particle development and assessment.
  • Microfluidics facilitates the creation of sophisticated in vivo-mimicking models for comprehensive drug delivery research.