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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Tumor Microenvironment02:17

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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
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Q&A: Mikala Egeblad on tumor microenvironment.

Mikala Egeblad, Suzanne Rose

    Cancer Discovery
    |May 6, 2014
    PubMed
    Summary
    This summary is machine-generated.

    The tumor microenvironment significantly impacts cancer treatment effectiveness and metastasis. Understanding this complex ecosystem is crucial for developing advanced cancer therapies and predicting disease progression.

    Area of Science:

    • Oncology
    • Cancer Biology
    • Immunology

    Background:

    • The tumor microenvironment (TME) is a complex ecosystem surrounding a tumor.

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  • It comprises cellular and non-cellular components that influence tumor growth and behavior.
  • The TME's role in therapeutic resistance and metastasis is an area of intense research.