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Updated: Apr 30, 2026

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia
Rathinaswamy Bhavanandhan Govindan1, An N Massaro2, Nickie N Andescavage2
1Division of Fetal and Transitional Medicine, Children's National Medical Center , Washington, DC , USA.
Abstract:
We extended our recent modification of the power spectral estimation approach to quantify spectral coherence. We tested both the standard and the modified approaches on simulated data, which showed that the modified approach was highly specific and sensitive to the coupling introduced in the simulation while the standard approach lacked these features. We also applied the modified and standard approaches to quantify the pressure passivity in 4 infants receiving therapeutic hypothermia. This was done by measuring the coupling between continuous cerebral hemoglobin differences and mean arterial blood pressure. Our results showed that the modified approach identified a lower pressure passivity index (PPI, percent time the coherence was above a predefined threshold) than the standard approach (P = 0.0027).
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