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[Production and characterization of monoclonal antibodies against allergen components]
A Petersen1, H Kahlert, H Jelke
1Forschungsinstitut Borstel, Medizinsche Klinik, Laborgruppe Allergologie.
Immunitat Und Infektion
|October 1, 1989
Abstract:
Monoclonal antibodies are useful tools for characterizing components causing type I allergy. Three aspects in production and characterization of monoclonal antibodies are discussed: 1. production of monoclonal antibodies raised against a special allergen of rye pollen extract. 2. investigation of monoclonal antibodies raised against peptide fragments of ovalbumin, 3. analysis of epitopes on allergenic components of timothy pollen extracts. The results indicate that monoclonal antibodies raised against certain allergens are useful for isolation of allergenic components and epitope mapping.