Related Experiment Video
Updated: Jan 31, 2026
09:43
The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents
Published on: August 10, 2014
47.0K
Impulsivity and attentional dysfunction in DAT-AAA knock-in mice.
C M Fitzpatrick1, J C McGirr2, A Petersen3
1Biomed Central, Springer Nature Group, The Campus, 4 Crinan Street, London N1 9XW, United Kingdom.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|January 29, 2026
Summary
Mice with reduced dopamine transporter (DAT) expression exhibit inattention and impulsivity, mirroring attention deficit hyperactivity disorder (ADHD) symptoms. This DAT-AAA mouse model offers new insights into ADHD neurobiology.
Area of Science:
- Neuroscience
- Behavioral Neuroscience
Background:
- Aberrant dopaminergic signaling is linked to attention deficit hyperactivity disorder (ADHD) core symptoms.
- Previous studies showed DAT-AAA mice have locomotor hyperactivity and altered reward processing due to reduced dopamine transporter (DAT) expression.
Purpose of the Study:
- To investigate attention and impulsivity in DAT-AAA mice.
- To assess the utility of the DAT-AAA mouse as a model for ADHD.
Main Methods:
- Utilized the 5-choice serial reaction time task (5-CSRTT) with variable stimulus duration and intertrial intervals.
- Employed Theory of Visual Attention (TVA) modeling for performance analysis.
- Conducted open field tests to evaluate anxiety-related behaviors.
Main Results:
- DAT-AAA mice displayed higher premature responding rates, indicating impulsivity.
- These mice showed significant inattention in variable stimulus duration tests.
- TVA modeling revealed a specific deficit in visual processing speed in DAT-AAA mice.
- Increased anxiety-related behavior was observed in DAT-AAA mice.
Conclusions:
- Reduced striatal DAT expression is associated with inattentive and impulsive behaviors.
- The DAT-AAA mouse model exhibits face validity for ADHD, showing hyperactivity, inattention, and impulsivity.
- This model may serve as a valuable tool for studying ADHD neurobiology.
Related Concept Videos
01:13Impulse
21.7K
According to Newton’s second law of motion, the rate of change of the momentum of an object is the net external force acting on it. The total change in momentum between two timepoints thus depends on both the external force acting on it and the time over which it acts. Describing this mathematically, the total change of an object’s motion is proportional to the force vector and the time over which it is applied. This product is called impulse.
Additionally, it can be shown that the...
Additionally, it can be shown that the...
21.7K
01:17Impulse Response
745
The impulse response is the system's reaction to an input impulse. In an RC circuit, the voltage source is the input, and the capacitor's voltage is the output. The system's state and output response before and after input excitation are distinctly defined.
Kirchhoff's law forms an input signal equation, with the capacitor's current and voltage providing the output. Substituting the current and dividing by RC yields a differential equation. The output for an impulse input is the impulse...
Kirchhoff's law forms an input signal equation, with the capacitor's current and voltage providing the output. Substituting the current and dividing by RC yields a differential equation. The output for an impulse input is the impulse...
745
01:15Principle of Impulse and Moment
519
When one considers a rigid body undergoing a plane motion, which is essentially a blend of translational and rotational movement, the application of Newton's second law gives the formula for the translational movement of such a body. If this equation is multiplied by a time interval, dt, and then integrated over the limits of integration, it results in an equation that embodies the principle of linear impulse.
519
00:49Impulse-Momentum Theorem
19.4K
The total change in the motion of an object is proportional to the total force vector acting on it and the time over which it acts. This product is called impulse, a vector quantity with the same direction as the total force acting on the object.
By writing Newton's second law of motion in terms of the momentum of an object and the external force acting on it, and simultaneously using the definition of the impulse vector, it can be shown that the total impulse on an object is equal to its...
By writing Newton's second law of motion in terms of the momentum of an object and the external force acting on it, and simultaneously using the definition of the impulse vector, it can be shown that the total impulse on an object is equal to its...
19.4K
01:19Principle of Angular Impulse and Momentum: Problem Solving
522
Consider a ball of mass m, attached to a massless rod of known length, subjected to a time-dependent torque. If the initial velocity of the mass is known, then the final velocity of the mass for time t can be determined using the principle of angular impulse and momentum.
Initially, a free-body diagram of the system is drawn to illustrate all the forces acting upon the system, providing a crucial understanding of the dynamics at play. Then, the principle of angular impulse and momentum is...
Initially, a free-body diagram of the system is drawn to illustrate all the forces acting upon the system, providing a crucial understanding of the dynamics at play. Then, the principle of angular impulse and momentum is...
522
01:23Principle of Angular Impulse and Momentum
1.3K
The angular impulse and momentum principle provides insights into how forces applied at a distance from an object's rotational axis influence its angular velocity. It builds upon the crucial relationship between the moment of force and angular momentum. By integrating this equation, substituting the limits for the initial and final times, a comprehensive expression representing the angular impulse and momentum principle is derived.
1.3K