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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Apr 30, 2026

Functional Calcium Imaging in Developing Cortical Networks

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

Dual-frequency calcium-responsive MRI agents.

Pascal Kadjane¹, Carlos Platas-Iglesias, Philipp Boehm-Sturm

¹Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076 Tübingen (Germany).

Chemistry (Weinheim an Der Bergstrasse, Germany)

|May 7, 2014

Summary

This summary is machine-generated.

Researchers developed novel dual-frequency magnetic resonance imaging (MRI) contrast agents. These smart agents detect calcium levels, offering new possibilities for functional MRI methods.

Keywords:

calcium fluorine imaging agents magnetic resonance imaging

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Area of Science:

Biomedical Imaging
Molecular Sensors
Contrast Agents

Background:

Responsive or smart magnetic resonance imaging (MRI) contrast agents act as molecular sensors, altering MRI signals in response to microenvironmental changes.
These agents enable visualization of biochemical events at molecular and cellular levels.

Purpose of the Study:

To report a series of dual-frequency calcium-responsive MRI agents.
To investigate the underlying mechanisms of Ca(2+)-triggered signal changes.
To assess the potential for developing novel functional MRI methods.

Main Methods:

Synthesis of paramagnetic, fluorine-containing complexes.
Evaluation of MRI signal changes at both (1)H and (19)F frequencies.
Analysis of agent response to varying Ca(2+) concentrations.

Main Results:

The developed agents exhibit high MRI signal changes at dual frequencies ((1)H and (19)F).
Signal alterations are dependent on calcium ion (Ca(2+)) concentrations.
The study elucidated the Ca(2+)-triggered processes within these agents.

Conclusions:

The novel dual-frequency tracers demonstrate significant potential for advanced functional MRI.
Understanding the Ca(2+)-triggered mechanisms facilitates agent improvement.
These agents represent a promising advancement in molecular and cellular imaging.