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Related Experiment Videos

CD19 is functionally and physically associated with surface immunoglobulin.

J M Pesando1, L S Bouchard, B E McMaster

  • 1Biomembrane Institute, Seattle, Washington 98119.

The Journal of Experimental Medicine
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

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B cell antigen receptor studies reveal CD19 antigen comodulation with surface immunoglobulin (sIg) upon anti-immunoglobulin antibody binding. This suggests CD19 is integral to the B cell receptor, potentially aiding signal transduction.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Surface immunoglobulin (sIg) and CD19 are key B cell surface proteins.
  • The functional relationship between sIg and CD19 remains incompletely understood.

Purpose of the Study:

  • To investigate the physical and functional association between sIg and CD19 on B cells.
  • To determine if CD19 is a component of the B cell antigen receptor (BCR).

Main Methods:

  • Incubation of mature B cells with various anti-immunoglobulin (anti-Ig) monoclonal antibodies (mAbs).
  • Analysis of CD19 antigen expression and localization using CD19-specific mAbs.
  • Assessment of sIg and CD19 comodulation and cocapping.

Main Results:

Related Experiment Videos

  • Anti-Ig antibodies induce rapid, reversible, and concentration-dependent comodulation of CD19 with sIg.
  • Comodulation of CD19 occurs with multiple anti-Ig specificities and CD19 epitopes.
  • CD19 is the only surface antigen among 18 studied to be comodulated with sIg.
  • sIg and CD19 loss occurs concurrently during anti-Ig modulation, indicating parallel events.
  • Anti-Ig treatment leads to cocapping and internalization of anti-CD19 mAb, suggesting physical association.

Conclusions:

  • CD19 is functionally and physically associated with sIg on B cells.
  • CD19 is proposed to be a component of the B cell antigen receptor.
  • CD19 may play a role in facilitating signal transduction initiated by sIg-antigen complexes.